Custom Peptides
Cayman Chemical 8-dehydro Cholesterol 10mg
An isomer of 7-DHC; accumulates in tissues and plasma in patients with SLOS; levels are increased in serum in a rat model of SLOS induced by AY 9944
Cayman Chemical ProstaglndIn F1a Alcohol 10mg
PGF1α alcohol is an analog of PGF1α with a primary alcohol replacing the C-1 carboxyl group. There are no published reports on the biological activity of this compound; however, the corresponding PGE1 analog (Item No. 13020) is a relatively selective EP3 and EP4 receptor ligand.{6640}
Cayman Chemical BetazolehydrochlorIde 10mg
A histamine H2 receptor agonist; induces acid secretion in isolated human gastric glands (EC50 = 120 µM); increases pepsin and acid levels in gastric juice in dogs at 3-10 mg/kg
Cayman Chemical R-Butaprost 10mg
Source Actve recombnant human renn expressed n HEK293 cells Amno acds 67-406 (full-length mature proten) MW 40 kDa
Cayman Chemical nlfInavIrmesylate 10mg
An orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM) that is used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection
Cayman Chemical FadrozolehydrochlorIde 10mg
A non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively); selectively inhibits LH-induced estrogen over progesterone production in hamster ovarian tissue as well as ACTH-induced corticosterone and aldosterone production in rat adrenal tissue (IC50s = 0.03, 160, 100, and 1 μM, respectively); decreases ovarian estrogen levels in rats (0.26 mg/kg); inhibits growth of androstenedione-stimulated mammary D2 cells implanted in mice by 95% (0.5 mg per animal per day)
Cayman Chemical O-Demethyl ApremIlast 10mg
An active metabolite of apremilast; inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated PBMCs (IC50s = 8.3 and 5.6 µM, respectively); an oxidative degradation product of apremilast
Cayman Chemical 4 5-DIcaffeoylquInIc AcId 10mg
A polyphenol with diverse biological activities; inhibits HIV-1 integrase 3' end processing, 3’ end joining, and disintegration (IC50s = 0.13, 0.24, and 0.3 μg/ml, respectively); inhibits HIV-1 replication in MT-2 T lymphoblastoid cells (EC50 = 2 UG/ml); scavenges DPPH radicals in a cell-free assay (IC50 = 19.8 µM) and inhibits superoxide production in human neutrophils activated by fMLF and cytochalasin B (IC50 = 1.49 µM); decreases PGE2 production in LPS-stimulated U937 cells at 5 and 10 UG/ml but increases it at 200 UG/ml and increases TNF-α production at 5-200 UG/ml; inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis in B16F1 murine melanocytes at 25 µM
Cayman Chemical 2 3-MDMAhydrochlorIde 10mg
An aromatic positional isomer of 3,4-MDMA (ecstasy) that exhibits a similar potency to 3,4-MDMA for inhibition of the noradrenalin transporter (IC50s = 6.2 and 6.6 μM, respectively) but is less potent than 3,4-MDMA for inhibition of the serotonin transporter (IC50s = 82 μM and 34.8 μM, respectively)
Cayman Chemical MetrIzamIde 10mg
A non-ionic contrast agent; does not induce EEG abnormalities in rabbits at 0.1 ml/kg of a 370 mg I/ml solution; has been used as a solute in gradient centrifugation applications
Cayman Chemical F1trIfluoroacetate salt 10mg
An anti-inflammatory peptide; inhibits LPS-induced phosphorylation of IKKα and IKKβ and nuclear translocation of NF-κB (p65) in isolated mouse peritoneal macrophages at 5 µM; decreases serum levels of IL-6, TNF-α, and IL-1β and increases survival in a mouse model of LPS-induced sepsis at 5 mg/kg
Cayman Chemical DavuntIdeacetate 10mg
A neuroprotective ADNP-derived peptide; promotes tubulin assembly in a cell-free assay at 1 fM; protects against cytotoxicity induced by tetrodotoxin, a peptide derived from Aβ, or zinc in isolated neonatal cerebral cortical cells at 1 fM; intravitreal administration inhibits increases in cleaved caspase-3 and decreases in Bcl-2 in retina isolated from streptozotocin-induced diabetic rats; improves survival in a SOD1G93A transgenic mouse model of ALS at 10 UG/animal; prevents decreases in brain ChAT activity and prevents memory deficits in the Morris water maze in an Apoe-/- mouse model of neurodegeneration
Cayman Chemical 1PalmItoyl2Oleoyl3Stearo 10mg
A triacylglycerol; one of the primary triacylglycerols found in cocoa butter
Cayman Chemical L-3-n-ButylphthalIde 10mg
A phthalide with antiplatelet and neuroprotective activities; inhibits ADP-, collagen-, and arachidonic acid-induced platelet aggregation ex vivo at 3-100 mg/kg; inhibits thrombus formation in a collagen and epinephrine-induced rat model of experimental thrombosis; reduces amyloid-β-induced decreases in GPX activity and decreases MDA levels in the cortex and hippocampus and improves spatial learning and memory in the Morris water maze in a rat model of Alzheimer’s disease induced by i.c.v. infusion of amyloid-β (1-40)